John Wayne Casserole Recipe
If you’re searching for a dish that delivers maximum flavor with minimal fuss, look no further than this John Wayne Casserole Recipe. Layered with hearty ground beef, tangy tomatoes, a golden Bisquick crust, and creamy cheese, it’s the ultimate comfort food with a spicy Tex-Mex kick. Whether you’re feeding a hungry crowd or just looking for a cozy family meal, this casserole transforms simple ingredients into a mouthwatering masterpiece you’ll want to make again and again.

Ingredients You’ll Need
This John Wayne Casserole Recipe shines with everyday ingredients you might already have in your kitchen. Each component is carefully chosen to build layers of bold flavor, satisfying textures, and eye-catching color.
- Ground Beef (1 pound): The protein-packed heart of the casserole, providing savory richness in every bite.
- Taco Seasoning Mix (1 packet): A shortcut to Tex-Mex flavor, giving the meat that irresistible zesty punch.
- Water (⅔ cup for beef, ½ cup for Bisquick): Helps blend seasonings into the beef and brings the Bisquick dough together for a tender crust.
- Diced Tomatoes with Green Chilies (1 can, 10 oz, drained): Bright and tangy with a hint of heat, this classic combo adds juicy texture and flavor depth.
- Diced Green Chiles (1 can, 4 oz; optional): For those who like it spicier, these mild green chiles bring an extra layer of Southwest flair.
- Sour Cream (1 cup): Creamy and slightly tangy, it balances the spice and keeps the casserole moist.
- Mayonnaise (½ cup): Lends extra creaminess and helps the cheesy layer melt just right.
- Shredded Cheddar Cheese (1½ cups, divided): That melty, golden cheese pull on top is non-negotiable!
- Onion (1 small, thinly sliced): Adds sweetness and a subtle crunch to cut through the richness.
- Bell Pepper (1, sliced): Brings color, freshness, and a gentle crispness to the cheesy topping.
- Bisquick Baking Mix (2 cups): The magical shortcut for a fluffy, biscuit-like base you don’t have to fuss over.
How to Make John Wayne Casserole Recipe
Step 1: Prepare the Meat Filling
Begin by browning your ground beef in a large skillet over medium heat. Stir and break up any large chunks so it cooks evenly and gets nice and crumbly. Once the beef is browned and cooked through, drain off any excess fat. Sprinkle in the taco seasoning mix, pour in ⅔ cup water, and simmer for five minutes, letting all those bold Tex-Mex flavors soak into the meat. By the time you’re done, the mixture should be thick and irresistibly aromatic.
Step 2: Mix and Press the Biscuit Crust
In a medium bowl, combine the Bisquick baking mix with ½ cup water. Stir until it just comes together into a soft dough—it should be sticky but manageable. Grease a 9×13-inch baking dish, then gently press the dough across the bottom to form an even crust. This step guarantees every serving will have a fluffy, biscuit-like base that pairs perfectly with the zippy topping.
Step 3: Assemble the Layers
Spoon your prepared beef mixture onto the biscuit crust, spreading it out evenly. Next, layer on the drained tomatoes with green chilies and the optional diced green chiles. These layers create bursts of flavor and juiciness that complement the hearty base.
Step 4: Mix and Spread the Creamy Topping
Whisk together the sour cream, mayonnaise, ½ cup of shredded cheddar cheese, and thinly sliced onion in a separate bowl. This ultra-creamy layer is the secret to making this John Wayne Casserole Recipe so luscious. Spread this mixture gently over the tomato layer, making sure to cover the surface evenly.
Step 5: Finish with Peppers and Cheese, Then Bake
Arrange the sliced bell pepper over the creamy layer for a pop of color and crunch. Sprinkle the remaining 1 cup of shredded cheddar on top—trust me, you’ll want that gooey melted cheese! Bake in a 350°F oven for 35–40 minutes until the casserole is bubbling and golden brown. Let it cool slightly so the layers set, then dig in!
How to Serve John Wayne Casserole Recipe

Garnishes
Elevate each serving with a sprinkle of fresh chopped cilantro or sliced green onions to add brightness. Want extra flair? A few slices of ripe avocado, dollops of extra sour cream, or a scattering of jalapeño rounds can make this John Wayne Casserole Recipe a showstopper at any gathering.
Side Dishes
This hearty casserole pairs well with simple sides that let its bold flavors shine. Try serving with a crisp green salad tossed in lime vinaigrette, a scoop of Mexican rice, or a side of black beans. Warm cornbread or tortilla chips are also fun for scooping up every last bite!
Creative Ways to Present
Serving this dish at a party? Cut the casserole into smaller squares and add toothpicks for easy finger food. You can also serve it burrito-style in warm tortillas, or make individual ramekins for personalized portions. However you plate it, this John Wayne Casserole Recipe is sure to impress.
Make Ahead and Storage
Storing Leftovers
Once completely cooled, cover the casserole tightly with plastic wrap or foil, or transfer portions to airtight containers. It keeps beautifully in the refrigerator for up to 3 days, making it a great option for meal-prep or next-day lunches.
Freezing
This casserole freezes surprisingly well! Wrap individual portions or the entire baking dish (if freezer-safe) with a double layer of plastic wrap and foil. Label it and pop it in the freezer for up to 2 months. Thaw overnight in the fridge before reheating for best results.
Reheating
For the best texture, reheat slices of John Wayne Casserole Recipe in a 350°F oven until warmed through, about 15-20 minutes. For a quicker option, use the microwave, but cover loosely to keep moisture in. Add a little extra cheese on top before reheating for that fresh-from-the-oven effect!
FAQs
Can I make this casserole in advance?
Absolutely! You can assemble the entire John Wayne Casserole Recipe a day ahead, cover tightly, and chill in the fridge. Just bake when ready—add 5 extra minutes to allow for the chill, and enjoy.
Can I use ground turkey or chicken instead of beef?
Yes, ground turkey or chicken works great as a lighter alternative. Just make sure to season well and cook thoroughly; the flavors really soak into whichever meat you use.
Is there a gluten-free version?
Definitely! Swap out Bisquick for your favorite gluten-free baking mix and double-check that your taco seasoning is gluten-free. The rest of the ingredients are naturally gluten-free, so everyone can dig in.
What can I add for extra veggies?
Feel free to add black beans, corn, zucchini, or even spinach to the layers for extra nutrition and color. The John Wayne Casserole Recipe is incredibly adaptable, so use what you love.
How spicy is this dish?
The heat level is pretty mild, especially if you skip the optional green chiles. If you want more kick, add some jalapeño slices, hot sauce, or spicy taco seasoning to the mix!
Final Thoughts
If you’re craving a meal that never disappoints, this John Wayne Casserole Recipe will quickly become your new go-to. There’s just something magical about all those comforting layers coming together in one cheesy, savory bake. Try it soon and let its old-fashioned flavor win you over!
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John Wayne Casserole Recipe
- Total Time: 1 hour
- Yield: 8 servings 1x
- Diet: Non-Vegetarian
Description
This John Wayne Casserole recipe is a Tex-Mex delight that’s perfect for busy weeknights. Layers of seasoned ground beef, tangy tomatoes, creamy cheese, and a Bisquick crust come together to create a hearty and satisfying dish that the whole family will love.
Ingredients
For the Beef Layer:
- 1 pound ground beef
- 1 packet taco seasoning mix
- ⅔ cup water
For the Tomato Layer:
- 1 can (10 oz) diced tomatoes with green chilies (drained)
- 1 can (4 oz) diced green chiles (optional)
For the Creamy Layer:
- 1 cup sour cream
- ½ cup mayonnaise
- 1½ cups shredded cheddar cheese (divided)
- 1 small onion (thinly sliced)
For the Bisquick Crust:
- 2 cups Bisquick baking mix
- ½ cup water
Instructions
- Preheat oven to 350°F. In a skillet, cook the ground beef until browned. Drain excess fat and stir in taco seasoning and water. Simmer for 5 minutes.
- Prepare the Bisquick crust: Combine Bisquick and water to form a dough. Press into a greased 9×13-inch baking dish.
- Layer the casserole: Spread the cooked beef over the crust, then add the tomatoes with green chilies and green chiles. In a bowl, mix sour cream, mayonnaise, ½ cup cheddar, and sliced onion. Spread over the tomato layer.
- Top and bake: Add bell peppers and remaining cheddar. Bake for 35–40 minutes until golden brown. Let cool before serving.
Notes
- Feel free to use store-bought biscuit dough for convenience.
- Enhance with black olives, jalapeños, or crushed tortilla chips for extra flavor.
- Prep Time: 20 minutes
- Cook Time: 40 minutes
- Category: Main Course
- Method: Baking
- Cuisine: Tex-Mex
Nutrition
- Serving Size: 1 square
- Calories: 480
- Sugar: 4g
- Sodium: 790mg
- Fat: 32g
- Saturated Fat: 12g
- Unsaturated Fat: 17g
- Trans Fat: 0g
- Carbohydrates: 25g
- Fiber: 2g
- Protein: 23g
- Cholesterol: 85mg